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Chronic Pain Research


Bjordal, J., Couppe,C., Chow, R., Tuner, J., Ljunggren, E. (2003).
A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders. Australian Journal of Physiotherapy 49(2):107-16.

Woodburn, J., Helliwell, P.S. (1997). Foot problems in rheumatology. British Journal of Rheumatology 36(9):932-4.

Li, L. (2005). What else can I do but take drugs: The future of research on nonpharmacological treatment in early inflammatory arthritis. Journal of Rheumatology Supplement 72:21-4.

Human Studies

Moore K C, Hira N, Kumar P S, Jaykumar C S & Ohshiro T (1989).
A Double Blind Crossover Trial of Low Level Laser Therapy in the Treatment of Post Herpetic Neuralgia. Laser Therapy 1 (1):7-9. Abstract: Post herpetic neuralgia can be an extremely painful condition which in many cases proves resistant to all the accepted forms of treatment. It is frequently most severe in the elderly and may persist for years with no predictable course. This trial was designed as a double blind assessment of the efficacy of low level laser therapy in the relief of the pain of post herpetic neuralgia with patients acting as their own controls. Admission to the trial was limited to patients with established post herpetic neuralgia of at least six months duration and who had shown little or no response to conventional methods of treatment. Measurements of pain intensity and distribution were noted over a period of eight treatments in two groups of patients each of which received four consecutive laser treatments. The results demonstrate a significant reduction in both pain intensity and distribution following a course of low level laser therapy.

Soriano, F., Campana, V., Moya, M., Gavotto, A., Simes, J., Soriano, M., Soriano, R., Spitale, L., Palma, J. (2006). Photobiomodulation of pain and inflammation in microcrystalline arthropathies: experimental and clinical results. Photomedicine & Laser Surgery 24(2): 140-150.Djavid,G.E., Mehrdad, R.,

Ebneshahidi N S, Heshmatipour M, Moghaddami A & Eghtesadi-Araghi P (2005). The Effects of Laser Acupuncture on Chronic Tension Headache – A Radomised Controlled Trial. Acupuncture in Medicine, 23 (1): 13-18.

Naeser M A (2006). Photobiomodulation of Pain in Carpal Tunnel Syndrome: Review of Seven Laser Therapy Studies. Photomedicine and Laser Surgery, 24 (2):101-110.

Mizokami T, Aoki K, Iwabuchi S, Kasai K, Yamazaki Y, Sakurai T, Samejima K & Yoshii N (1993). LLLT (Lower Reactive Level Laser Therapy) – A Clinical Study: Relationship between Pain Attenuation and the Serotonergic Mechanism. Laser Therapy, 5:165-168.

Ghasemi, M., Hasan-Zadeh, H., Sotoodeh-Manesh, A. & Pouryaghoub, G. (2007). In chronic low back pain, low level laser therapy combined with exercise is more beneficial than exercise alone in the long term: a randomised trial. Australian Journal of Physiotherapy 53:155-160.

Ainman LH, Ngo M, Ng E T, Nwe T, Gogov S & Bril V (2004). Low-Intensity Laser Therapy for Painful Symptoms of Diabetic Sensorimotor Polyneuropathy. Diabetes Care, 27:921-924.

Gur, A., Karakoc, M., Nas, K. et al (2002). Efficacy of low power laser therapy in fibromyalgia. Lasers Med Sci 17(1):57-61.

Yurtkuran, M., Konur, S., Ozcakir, S., Bingol, U. (2007). Laser Acupuncture in Knee Osteoarthritis: A Double-Blind, Randomised Controlled Study. Photomedicine & Laser Surgery 25 (1):14-20.

Brosseau, L., Gam, A., Harman, K., Morin, M. et al (2005). Low level laser therapy (classes I,II and III) for treating rheumatoid arthritis. The Cochrane Library, Issue 1.

Brosseau, L., Gam, A., Harman, K., Morin, M. et al (2004). Low level laser therapy (classes I,II and III) for treating osteoarthritis. The Cochrane Library, Issue 3.

Brosseau, L., Wells, G., Marchand, S., Baboury, I. et al (2005). Randomised controlled trial on LLLT in the treatment of osteoarthritis of the hand. Lasers in Surgery & Medicine 36(3): 210-219.

Hirschl, M., Katzenschlager, R., Ammer, K., Melnizky, P. et al (2002). Double blind, randomised, placebo controlled low level laser therapy study in patients with primary Raynaud’s phenomenon. VASA 31(2):91-4.

Al Awami M, Schillinger M, Gschwandtner M E et al (2001). Low level laser treatment of primary and secondary Raynaud's phenomenon. VASA 30 (4): 281-284.

Hirschl, M., Katzenschlager, R., Francesconi, C., Kundi, M. (2004). Low level laser therapy in primary Raynaud’s phenomenon. Journal of Rheumatology 31(12):2408-12.

Mirko Hirschl, Reinhold Katzenschlager, Claudia Francesconi, And Michael Kundi (2004). Low Level Laser Therapy in Primary Raynaud's Phenomenon — Results of a Placebo Controlled, Double Blind Intervention Study From the Department of Angiology, Hanusch Hospital, Vienna; and the Institute of Environmental Health, Medical University of Vienna, Vienna, Austria.

Al-Awami M, Schillinger M, Maca T, Pollanz S, Minar E. Low level laser therapy for treatment of primary and secondary Raynaud's phenomenon. Department of Medical Angiology, University of Vienna, Austria.

In Vitro Studies

Walsh D, Baxter G D, Allen JM (1995). T
he effect of 820nm Laser irradiation upon conduction in the frog ( rana temporaria) sciatic nerve in vitro. Laser Therapy, 7: 5-10.

Lin. Y et al (2004). Effects of NeNe laser on levels of stress protein and arthritic histopathology in experimental osteoarthritis. American Journal of Physical Medicine and Rehabilitation 83(10):758-765.

Laser Research